![]() |
Center for Open Access in Science (COAS) OPEN JOURNAL FOR PSYCHOLOGICAL RESEARCH (OJPR) ISSN (Online) 2560-5372 * ojpr@centerprode.com |
Exploring the Psychological Risk Factors in Children with Epilepsy Mimoza Maloku Kuqi Hazir Elshani Eglantina Dervishi * egladervishi@yahoo.com * ORCID: 0000-0003-1015-1948 * ResearcherID: T-6964-2018 Silva Ibrahimi * ibrahimi.silva@gmail.com * ORCID: 0000-0003-3233-1157 * ResearcherID: N-5693-2018 Open Journal for Psychological Research, 2020, 4(2), 109-122 * https://doi.org/10.32591/coas.ojpr.0402.04109m LICENCE: Creative Commons Attribution 4.0 International License. ARTICLE (Full Text - PDF) |
ABSTRACT: KEY WORDS: epilepsy, children, cognitive impairments, general intelligence, behavioral problems, EEG, MRI. CORRESPONDING AUTHOR: |
REFERENCES: Abstracts from the 51st European Society of Human Genetics Conference: Posters. (2019). European Journal of Human Genetics, 27(Suppl 1), 1-688. https://doi.org/10.1038/s41431-019-0404-7 Aicua-Rapun, I., André, P., & Novy, J. (2019). Closed-loop neuropharmacology for epilepsy: Distant dream or future reality? Current Neuropharmacology, 17(5), 447-458. https://doi.org/10.2174/1570159X16666180308154646 Aliyu, M. H., Abdullahi, A. T., Iliyasu, Z., Salihu, A. S., Adamu, H., Sabo, U., Garcia, J. P., Abdullahi, S. U., Mande, A., Xian, H., Yakasai, H. M., Schootman, M., Ingles, D. J., Patel, A. A., Yakasai, A., Curry-Johnson, S., Wudil, U. J., DeBaun, M. R., Trevathan, E., & BRIDGE Advisory Panel (2019). Bridging the childhood epilepsy treatment gap in northern Nigeria (BRIDGE): Rationale and design of pre-clinical trial studies. Contemporary Clinical Trials Communications, 15, 100362. https://doi.org/10.1016/j.conctc.2019.100362 Andresen, E. N., Ramirez, M. J., Kim, K. H., Dorfman, A. B., Haut, J. S., Klaas, P. A., Jehi, L. E., Shea, K., Bingaman, W. E., & Busch, R. M. (2014). Effects of surgical side and site on mood and behavior outcome in children with pharmacoresistant epilepsy. Frontiers in Neurology, 5, 18. https://doi.org/10.3389/fneur.2014.00018 Berg, A. T., Zelko, F. A., Levy, S. R., & Testa, F. M. (2012). Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes: A prospective cohort study. Neurology, 79(13), 1384-1391. https://doi.org/10.1212/WNL.0b013e31826c1b55 Boshuisen, K., Lamberink, H. J., van Schooneveld, M. M., Cross, J. H., Arzimanoglou, A., van der Tweel, I., Geleijns, K., Uiterwaal, C. S., & Braun, K. P. (2015). Cognitive consequences of early versus late antiepileptic drug withdrawal after pediatric epilepsy surgery, the TimeToStop (TTS) trial: study protocol for a randomized controlled trial. Trials, 16, 482. https://doi.org/10.1186/s13063-015-0989-2 Brooks-Kayal, A. R., Bath, K. G., Berg, A. T., Galanopoulou, A. S., Holmes, G. L., Jensen, F. E., Kanner, A. M., O'Brien, T. J., Whittemore, V. H., Winawer, M. R., Patel, M., & Scharfman, H. E. (2013). Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia, 54 Suppl 4(0 4), 44-60. https://doi.org/10.1111/epi.12298 Bulaj, G., Ahern, M. M., Kuhn, A., Judkins, Z. S., Bowen, R. C., & Chen, Y. (2016). Incorporating natural products, pharmaceutical drugs, self-care and digital/mobile health technologies into molecular-behavioral combination therapies for chronic diseases. Current Clinical Pharmacology, 11(2), 128-145. https://doi.org/10.2174/1574884711666160603012237 Burke, S. L., Naseh, M., Rodriguez, M. J., Burgess, A., & Loewenstein, D. (2019). Dementia-related neuropsychological testing considerations in non-Hispanic white and Latino/Hispanic populations. Psychology & Neuroscience, 12(2), 144-168. https://doi.org/10.1037/pne0000163 Cacabelos R. (2020). Pharmacogenomics of cognitive dysfunction and neuropsychiatric disorders in dementia. International Journal of Molecular Sciences, 21(9), 3059. https://doi.org/10.3390/ijms21093059 Chang, B. S., Krishnan, V., Dulla, C. G., Jette, N., Marsh, E. D., Dacks, P. A., Whittemore, V., Poduri, A., & NINDS/AES Epilepsy Research Benchmark Stewards Committee (2020). Epilepsy benchmarks area I: Understanding the causes of the epilepsies and epilepsy-related neurologic, psychiatric, and somatic conditions. Epilepsy Currents, 20(1_suppl), 5S-13S. https://doi.org/10.1177/1535759719895280, E. D., Dacks, P. A., Whittemore, V., Poduri, A., & NINDS/AES Epilepsy Research Benchmark Stewards. Coryell, J., Gaillard, W. D., Shellhaas, R. A., Grinspan, Z. M., Wirrell, E. C., Knupp, K. G., Wusthoff, C. J., Keator, C., Sullivan, J. E., Loddenkemper, T., Patel, A., Chu, C. J., Massey, S., Novotny, E. J., Jr, Saneto, R. P., & Berg, A. T. (2018). Neuroimaging of early life epilepsy. Pediatrics, 142(3), e20180672. https://doi.org/10.1542/peds.2018-0672 Crudgington, H., Rogers, M., Morris, H., Gringras, P., Pal, D. K., & Morris, C. (2020). Epilepsy-specific patient-reported outcome measures of children’s health-related quality of life: A systematic review of measurement properties. Epilepsia, 61(2), 230-248. https://doi.org/10.1111/epi.16430 Dabbs, K., Jones, J. E., Jackson, D. C., Seidenberg, M., & Hermann, B. P. (2013). Patterns of cortical thickness and the Child Behavior Checklist in childhood epilepsy. Epilepsy & Behavior: E&B, 29(1), 198-204. https://doi.org/10.1016/j.yebeh.2013.07.008 de Bruijn, M., van Sonderen, A., van Coevorden-Hameete, M. H., Bastiaansen, A., Schreurs, M., Rouhl, R., van Donselaar, C. A., Majoie, M., Neuteboom, R. F., Sillevis Smitt, P., Thijs, R. D., & Titulaer, M. J. (2019). Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABABR encephalitis. Neurology, 92(19), e2185-e2196. https://doi.org/10.1212/WNL.0000000000007475 de Bruijn, M., van Sonderen, A., van Coevorden-Hameete, M. H., Bastiaansen, A., Schreurs, M., Rouhl, R., van Donselaar, C. A., Majoie, M., Neuteboom, R. F., Sillevis Smitt, P., Thijs, R. D., & Titulaer, M. J. (2019). Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABABR encephalitis. Neurology, 92(19), e2185-e2196. https://doi.org/10.1212/WNL.0000000000007475 Dugger, S. A., Platt, A., & Goldstein, D. B. (2018). Drug development in the era of precision medicine. Nature reviews. Drug discovery, 17(3), 183-196. https://doi.org/10.1038/nrd.2017.226 E-Poster Viewing. (2019). European Stroke Journal, 4(1 Suppl), 150-276. https://doi.org/10.1177/2396987319845581 Fleming, M., Fitton, C. A., Steiner, M., McLay, J. S., Clark, D., King, A., Mackay, D. F., & Pell, J. P. (2019). Educational and health outcomes of children and adolescents receiving antiepileptic medication: Scotland-wide record linkage study of 766,244 schoolchildren. BMC Public Health, 19(1), 595. https://doi.org/10.1186/s12889-019-6888 Galanopoulou, A. S., & Moshé, S. L. (2015). Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies. Neurobiology of Disease, 79, 135-149. https://doi.org/10.1016/j.nbd.2015.04.015 Greaves, D., Psaltis, P. J., Ross, T. J., Davis, D., Smith, A. E., Boord, M. S., & Keage, H. (2019). Cognitive outcomes following coronary artery bypass grafting: A systematic review and meta-analysis of 91,829 patients. International Journal of Cardiology, 289, 43-49. https://doi.org/10.1016/j.ijcard.2019.04.065 Greenberg, D. A., & Subaran, R. (2011). Blinders, phenotype, and fashionable genetic analysis: A critical examination of the current state of epilepsy genetic studies. Epilepsia, 52(1), 1-9. https://doi.org/10.1111/j.1528-1167.2010.02734.x Grinspan, Z. M., Shellhaas, R. A., Coryell, J., Sullivan, J. E., Wirrell, E. C., Mytinger, J. R., Gaillard, W. D., Kossoff, E. H., Valencia, I., Knupp, K. G., Wusthoff, C., Keator, C., Ryan, N., Loddenkemper, T., Chu, C. J., Novotny, E. J., Jr, Millichap, J., & Berg, A. T. (2018). Comparative effectiveness of levetiracetam vs phenobarbital for infantile epilepsy. JAMA Pediatrics, 172(4), 352-360. https://doi.org/10.1001/jamapediatrics.2017.5211 Hamed S. A. (2009). The aspects and mechanisms of cognitive alterations in epilepsy: The role of antiepileptic medications. CNS Neuroscience & Therapeutics, 15(2), 134-156. https://doi.org/10.1111/j.1755-5949.2008.00062.x Hermann, B., Loring, D. W., & Wilson, S. (2017). Paradigm shifts in the neuropsychology of epilepsy. Journal of the International Neuropsychological Society: JINS, 23(9-10), 791-805. https://doi.org/10.1017/S1355617717000650 Hessen, E., Alfstad, K. Å., Torgersen, H., & Lossius, M. I. (2018). Tested and reported executive problems in children and youth epilepsy. Brain and Behavior, 8(5), e00971. https://doi.org/10.1002/brb3.971 Hirosawa, T., Kikuchi, M., Fukai, M., Hino, S., Kitamura, T., An, K. M., Sowman, P., Takahashi, T., Yoshimura, Y., Miyagishi, Y., & Minabe, Y. (2018). Association between magnetoencephalographic interictal epileptiform discharge and cognitive function in young children with typical development and with autism spectrum disorders. Frontiers in Psychiatry, 9, 568. https://doi.org/10.3389/fpsyt.2018.00568 Holmes G. L. (2014). What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data? Epileptic Disorders: International Epilepsy Journal with Videotape, 16 Spec No 1(Spec No 1), S12-S22. https://doi.org/10.1684/epd.2014.0686 Holmes G. L. (2016). Effect of seizures on the developing brain and cognition. Seminars in Pediatric Neurology, 23(2), 120-126. https://doi.org/10.1016/j.spen.2016.05.001 Izadi, A., Ondek, K., Schedlbauer, A., Keselman, I., Shahlaie, K., & Gurkoff, G. (2018). Clinically indicated electrical stimulation strategies to treat patients with medically refractory epilepsy. Epilepsia Open, 3(Suppl Suppl 2), 198-209. https://doi.org/10.1002/epi4.12276 Jacobs, C. S., Willment, K. C., & Sarkis, R. A. (2019). Non-invasive cognitive enhancement in epilepsy. Frontiers in Neurology, 10, 167. https://doi.org/10.3389/fneur.2019.00167 Jones, J. E., Asato, M. R., Brown, M. G., Doss, J. L., Felton, E. A., Kearney, J. A., Talos, D., Dacks, P. A., Whittemore, V., Poduri, A., & NINDS/AES Benchmarks Stewards Committee (2020). Epilepsy benchmarks area IV: Limit or prevent adverse consequence of seizures and their treatment across the life span. Epilepsy Currents, 20(1_suppl), 31S-39S. https://doi.org/10.1177/1535759719895277 Kalaria, R. N., Akinyemi, R., & Ihara, M. (2016). Stroke injury, cognitive impairment and vascular dementia. Biochimica et biophysica acta, 1862(5), 915-925. https://doi.org/10.1016/j.bbadis.2016.01.015 Kaushik, S., Chopra, D., Sharma, S., & Aneja, S. (2019). Adverse drug reactions of anti-epileptic drugs in children with epilepsy: A cross-sectional study. Current Drug Safety, 14(3), 217-224. https://doi.org/10.2174/1574886314666190311112710 Kim, E. H., & Ko, T. S. (2016). Cognitive impairment in childhood onset epilepsy: Up-to-date information about its causes. Korean Journal of Pediatrics, 59(4), 155-164. https://doi.org/10.3345/kjp.2016.59.4.155 Korthauer, L. E., Awe, E., Frahmand, M., & Driscoll, I. (2018). Genetic risk for age-related cognitive impairment does not predict cognitive performance in middle age. Journal of Alzheimer’s Disease: JAD, 64(2), 459-471. https://doi.org/10.3233/JAD-171043 Kossoff, E. H., Zupec-Kania, B. A., Auvin, S., Ballaban-Gil, K. R., Christina Bergqvist, A. G., Blackford, R., Buchhalter, J. R., Caraballo, R. H., Cross, J. H., Dahlin, M. G., Donner, E. J., Guzel, O., Jehle, R. S., Klepper, J., Kang, H. C., Lambrechts, D. A., Liu, Y., Nathan, J. K., Nordli, D. R., Jr, Pfeifer, H. H., … Practice Committee of the Child Neurology Society (2018). Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open, 3(2), 175-192. https://doi.org/10.1002/epi4.12225 Kynast, J., Lampe, L., Luck, T., Frisch, S., Arelin, K., Hoffmann, K. T., Loeffler, M., Riedel-Heller, S. G., Villringer, A., & Schroeter, M. L. (2018). White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 38(6), 996-1009. https://doi.org/10.1177/0271678X17719380 Lenck-Santini, P. P., & Scott, R. C. (2015). Mechanisms Responsible for Cognitive Impairment in Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(10), a022772. https://doi.org/10.1101/cshperspect.a022772 Makale, M. T., McDonald, C. R., Hattangadi-Gluth, J. A., & Kesari, S. (2017). Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumors. Nature Reviews. Neurology, 13(1), 52-64. https://doi.org/10.1038/nrneurol.2016.185 McTague, A., Martland, T., & Appleton, R. (2018). Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. The Cochrane Database of Systematic Reviews, 1(1), CD001905. https://doi.org/10.1002/14651858.CD001905.pub3 Mollon, J., Mathias, S. R., Knowles, E., Rodrigue, A., Koenis, M., Pearlson, G. D., Reichenberg, A., Barrett, J., Denbow, D., Aberizk, K., Zatony, M., Poldrack, R. A., Blangero, J., & Glahn, D. C. (2020). Cognitive impairment from early to middle adulthood in patients with affective and nonaffective psychotic disorders. Psychological Medicine, 50(1), 48-57. https://doi.org/10.1017/S0033291718003938 Munger Clary, H. M., Snively, B. M., & Hamberger, M. J. (2018). Anxiety is common and independently associated with clinical features of epilepsy. Epilepsy & Behavior: E&B, 85, 64-71. https://doi.org/10.1016/j.yebeh.2018.05.024 Nevitt, S. J., Sudell, M., Weston, J., Tudur Smith, C., & Marson, A. G. (2017). Antiepileptic drug monotherapy for epilepsy: A network meta-analysis of individual participant data. The Cochrane Database of Systematic Reviews, 12(12), CD011412. https://doi.org/10.1002/14651858.CD011412.pub3 Noebels J. L. (2015). Single-gene determinants of epilepsy comorbidity. Cold Spring Harbor Perspectives in Medicine, 5(11), a022756. https://doi.org/10.1101/cshperspect.a022756 O’Brien, F., Clapham, D., Krysiak, K., Batchelor, H., Field, P., Caivano, G., Pertile, M., Nunn, A., & Tuleu, C. (2019). Making medicines baby size: The challenges in bridging the formulation gap in neonatal medicine. International Journal of Molecular Sciences, 20(11), 2688. https://doi.org/10.3390/ijms20112688 Panebianco, M., Al-Bachari, S., Weston, J., Hutton, J. L., & Marson, A. G. (2018). Gabapentin add-on treatment for drug-resistant focal epilepsy. The Cochrane Database of Systematic Reviews, 10(10), CD001415. https://doi.org/10.1002/14651858.CD001415.pub3 Pardo, C. A., Nabbout, R., & Galanopoulou, A. S. (2014). Mechanisms of epileptogenesis in pediatric epileptic syndromes: Rasmussen encephalitis, infantile spasms, and febrile infection-related epilepsy syndrome (FIRES). Neurotherapeutics: The Journal of the American Society for Experimental Neurotherapeutics, 11(2), 297-310. https://doi.org/10.1007/s13311-014-0265-2. Parrish, J. B, & Fields, E. (2019). Cognitive functioning in patients with pediatric-onset multiple sclerosis, an updated review and future focus. Children (Basel, Switzerland) vol. 6, 2 21. 4 Feb. 2019, https://doi.org/10.3390/children6020021 Paudel, Y. N., Shaikh, M. F., Chakraborti, A., Kumari, Y., Aledo-Serrano, Á., Aleksovska, K., Alvim, M., & Othman, I. (2018). HMGB1: A common biomarker and potential target for TBI, neuroinflammation, epilepsy, and cognitive dysfunction. Frontiers in Neuroscience, 12, 628. https://doi.org/10.3389/fnins.2018.00628 Perry, W., Lacritz, L., Roebuck-Spencer, T., Silver, C., Denney, R. L., Meyers, J., McConnel, C. E., Pliskin, N., Adler, D., Alban, C., Bondi, M., Braun, M., Cagigas, X., Daven, M., Drozdick, L., Foster, N. L., Hwang, U., Ivey, L., Iverson, G., Kramer, J., … Golden, T. (2018). Population health solutions for assessing cognitive impairment in geriatric patients. Archives of Clinical Neuropsychology: The Official Journal of the National Academy of Neuropsychologists, 33(6), 655-675. https://doi.org/10.1093/arclin/acy052 Ping, X., Qin, S. K., Liu, S. N., Lu, Y., Zhao, Y. N., Cao, Y. F., Zhang, Y. H., Zhang, S. D., Chu, L., & Pei, L. (2019). Effects of Huazhuo Jiedu Shugan decoction on cognitive and emotional disorders in a rat model of epilepsy: Possible involvement of AC-cAMP-CREB signaling and NPY expression. Evidence-Based Complementary and Alternative Medicine: eCAM, 2019, 4352879. https://doi.org/10.1155/2019/4352879 Proceedings of Réanimation 2020, the French Intensive Care Society International Congress. (2020). Annals of Intensive Care, 10(Suppl 1), 16. https://doi.org/10.1186/s13613-020-0623-7 Ravizza, T., Onat, F. Y., Brooks-Kayal, A. R., Depaulis, A., Galanopoulou, A. S., Mazarati, A., Numis, A. L., Sankar, R., & Friedman, A. (2017). WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia, 58(3), 331-342. https://doi.org/10.1111/epi.13652 Reddy, S. D., Younus, I., Sridhar, V., & Reddy, D. S. (2019). Neuroimaging biomarkers of experimental epileptogenesis and refractory epilepsy. International Journal of Molecular Sciences, 20(1), 220. https://doi.org/10.3390/ijms20010220 Reilly, C., Atkinson, P., Memon, A., Jones, C., Dabydeen, L., Cross, J. H., Das, K. B., Gillberg, C., Neville, B., & Scott, R. C. (2018). Child and parental sleep in young children with epilepsy: A population-based case-control study. Epilepsia Open, 3(3), 383-391. https://doi.org/10.1002/epi4.12241 Semple, B. D., Zamani, A., Rayner, G., Shultz, S. R., & Jones, N. C. (2019). Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy. Neurobiology of Disease, 123, 27-41. https://doi.org/10.1016/j.nbd.2018.07.018 Shinnar, R. C., Shinnar, S., Cnaan, A., Clark, P., Dlugos, D., Hirtz, D. G., Hu, F., Liu, C., Masur, D., Weiss, E. F., Glauser, T. A., & Childhood Absence Epilepsy Study Group (2017). Pretreatment behavior and subsequent medication effects in childhood absence epilepsy. Neurology, 89(16), 1698-1706. https://doi.org/10.1212/WNL.0000000000004514 Silvestro, S., Mammana, S., Cavalli, E., Bramanti, P., & Mazzon, E. (2019). Use of cannabidiol in the treatment of epilepsy: Efficacy and security in clinical trials. Molecules (Basel, Switzerland), 24(8), 1459. https://doi.org/10.3390/molecules24081459 Suraev, A., Lintzeris, N., Stuart, J., Kevin, R. C., Blackburn, R., Richards, E., Arnold, J. C., Ireland, C., Todd, L., Allsop, D. J., & McGregor, I. S. (2018). Composition and use of cannabis extracts for childhood epilepsy in the Australian community. Scientific Reports, 8(1), 10154. https://doi.org/10.1038/s41598-018-28127-0 Vinciguerra, F., Graziano, M., Hagnäs, M., Frittitta, L., & Tumminia, A. (2020). Influence of the Mediterranean and ketogenic diets on cognitive status and decline: A narrative review. Nutrients, 12(4), 1019. https://doi.org/10.3390/nu12041019 Wang, L., Chen, S., Liu, C., Lin, W., & Huang, H. (2020). Factors for cognitive impairment in adult epileptic patients. Brain and Behavior, 10(1), e01475. https://doi.org/10.1002/brb3.1475 Wang, T. S., Liu, Q. Z., Liu, M., Zhang, Q., Wang, R. F., Wu, C. W., Zhang, J., Wang, W., Ji, T. Y., Liu, X. Y., Wang, S., Cai, L. X., Jiang, Y. W., & Wu, Y. (2020). Clinical features and surgical outcomes in young children with focal cortical dysplasia type II. CNS Neuroscience & Therapeutics, 26(2), 270-277. https://doi.org/10.1111/cns.13205 Williams, C. (2020). Reducing the burden of childhood cerebral visual impairment: another step forward. Developmental Medicine and Child Neurology, 62(1), 15. https://doi.org/10.1111/dmcn.14323 Yoong, M. (2015). Quantifying the deficit-imaging neurobehavioural impairment in childhood epilepsy. Quantitative Imaging in Medicine and Surgery, 5(2), 225-237. https://doi.org/10.3978/j.issn.2223-4292.2015.01.06 Zelko, F. A., Pardoe, H. R., Blackstone, S. R., Jackson, G. D., & Berg, A. T. (2014). Regional brain volumes and cognition in childhood epilepsy: Does size really matter? Epilepsy Research, 108(4), 692-700. https://doi.org/10.1016/j.eplepsyres.2014.02.003 Zhou, L., Chen, P., Peng, Y., & Ouyang, R. (2016). Role of oxidative stress in the neurocognitive dysfunction of obstructive sleep apnea syndrome. Oxidative Medicine and Cellular Longevity, 2016, 9626831. https://doi.org/10.1155/2016/9626831 |
© Center for Open Access in Science